RAF Typhoon FGR4s have operated alongside French warplanes in a combined operation against an underground arms cache in Syria employed by the IS group, according to the British defence ministry.
The location, identified by surveillance, was assessed as containing munitions and bombs, the announcement noted, and was positioned in hills just north of the historic site of Palmyra in Syria's central region.
"Our aircraft utilized Paveway IV guided bombs to target a series of approach shafts down to the site... early reports indicate the strike was effective," the ministry announced.
There was no sign of any harm to civilians in the attack on Saturday evening and all the aircraft made a safe return, the defence officials confirmed.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
Daesh - alternatively referred to as Daesh - imposed jihadist rule over parts of both Syria and Iraq before its territorial defeat in 2019.
"This strike demonstrates British leadership, and resolve to work closely with our allies, to stamp out any resurgence of the terrorist group and their harmful and extremist ideologies in the Middle East," the British Defence Secretary the Defence Secretary remarked.
British military aircraft have carried out overwatch operations over Syria to "prevent any efforts to regroup" of IS following its routing at the Baghuz confrontation in 2019, the authorities noted.
"I must thank all the members of our armed forces participating in this strike for their skill and their courage," Healey said. "They were part of numerous British personnel stationed over the holidays. This operation, to remove terrorist threats who threaten our way of life, demonstrates how British military are always on standby, throughout the year, protecting the UK domestically and strong abroad."
In December, the US military carried out what it called a "massive strike" targeting Daesh sites in the country, following an assault claimed the lives of two American soldiers and a local interpreter in the Palmyra area.
The UN estimates IS still maintains an estimated 5,000 to 7,000 fighters in Syria and Iraq.
